There is no doubt that aging populations present one of the biggest challenges in today’s world. Better understanding of the process of biological ageing is key to improving health and longevity in modern society. Human tissue has various levels of regenerative potential; tissue such as the adult heart and the central nervous system have very little power to regenerate, while skeletal muscle and skin have a remarkable ability to regenerate following injury. Research at HKUST is focusing on somatic stem cell biology and the signaling pathways involved in tissue regeneration as well as stem cell ageing. This talk examines how stem cells repair tissue in normal circumstances as well as during organismal ageing, particularly focusing on stem cell-mediated repairs.